Amino acid oxidase of leukocytes in relation to H 2 O 2 -mediated bacterial killing.

  title={Amino acid oxidase of leukocytes in relation to H 2 O 2 -mediated bacterial killing.},
  author={Markus Eckstein and Robert L. Baehner and David G. Nathan},
  journal={The Journal of clinical investigation},
  volume={50 9},
D-Amino acid oxidase and L-amino acid oxidase have been measured in sucrose homogenates of polymorphonuclear leukocytes (PMN) obtained from guinea pigs and humans. Subcellular distribution patterns and studies on latency indicate that these oxidases are soluble enzymes. Their hydrogen peroxide-generating capacity was verified. Chronic granulomatous disease PMN, which lack a respiratory burst and fail to generate H(2)O(2) during phagocytosis and do not kill catalase positive bacteria, had… CONTINUE READING
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