Amino acid homeostasis and signalling in mammalian cells and organisms

@inproceedings{Brer2017AminoAH,
  title={Amino acid homeostasis and signalling in mammalian cells and organisms},
  author={Stefan Br{\"o}er and Angelika Br{\"o}er},
  booktitle={The Biochemical journal},
  year={2017}
}
Cells have a constant turnover of proteins that recycle most amino acids over time. Net loss is mainly due to amino acid oxidation. Homeostasis is achieved through exchange of essential amino acids with non-essential amino acids and the transfer of amino groups from oxidised amino acids to amino acid biosynthesis. This homeostatic condition is maintained through an active mTORC1 complex. Under amino acid depletion, mTORC1 is inactivated. This increases the breakdown of cellular proteins through… CONTINUE READING
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