Amino acid-directed nucleic acid synthesis. A possible mechanism in the origin of life.

@article{Nelsestuen1978AminoAN,
  title={Amino acid-directed nucleic acid synthesis. A possible mechanism in the origin of life.},
  author={Gary L. Nelsestuen},
  journal={Journal of molecular evolution},
  year={1978},
  volume={11 2},
  pages={109-20}
}
The fact that proteins contain only alpha-amino acids and that protein structure is determined by 3' leads to 5' linked ribonucleotides is postulated to be the result of the copolymerization of these molecules in the prebiotic environment. Ribonucleotides therefore represent partial degradation products and proteins represent a side reaction developing from copolymerization. The basic structural unit of copolymerization is a nucleotide substituted with an amino acid at the 2' postion… CONTINUE READING