Amino acid deprivation regulates the stress-inducible gene p8 via the GCN2/ATF4 pathway.

@article{Avrous2011AminoAD,
  title={Amino acid deprivation regulates the stress-inducible gene p8 via the GCN2/ATF4 pathway.},
  author={Julien Av{\'e}rous and Sarah Lambert-Langlais and Yoan Ch{\'e}rasse and Val{\'e}rie Carraro and Laurent Parry and Wafa B'chir and C{\'e}line Jousse and A-S. Maurin and Alain Bruhat and Pierre Fafournoux},
  journal={Biochemical and biophysical research communications},
  year={2011},
  volume={413 1},
  pages={24-9}
}
In mammals, the GCN2/ATF4 pathway has been described as the main pathway involved in the regulation of gene expression upon amino acid limitation. This regulation is notably conferred by the presence of a cis-element called Amino Acid Response Element (AARE) in the promoter of specific genes. In vivo, the notion of amino acid limitation is not limited to nutritional context, indeed several pathological situations are associated with alteration of endogenous amino acid availability. This is… CONTINUE READING