Corpus ID: 19071098

Amino acid-dependent increase in hepatic system N activity is linked to cell swelling.

@article{Bode1991AminoAI,
  title={Amino acid-dependent increase in hepatic system N activity is linked to cell swelling.},
  author={B. Bode and M. Kilberg},
  journal={The Journal of biological chemistry},
  year={1991},
  volume={266 12},
  pages={
          7376-81
        }
}
  • B. Bode, M. Kilberg
  • Published 1991
  • Biology, Medicine
  • The Journal of biological chemistry
Treatment of cultured rat hepatocytes with certain amino acids stimulates the activity of the System N transporter. The present report investigates the mechanism by which the stimulatory amino acids elicit their effect. Activation of System N-mediated transport by amino acids is rapid, cycloheximide-insensitive, and involves neither trans-stimulation nor recruitment of additional carriers to the plasma membrane. In addition, the activation is Na(+)-dependent, supporting the related observation… Expand
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