Amino acid deficiency and the skin rash associated with glucagonoma.

@article{Norton1979AminoAD,
  title={Amino acid deficiency and the skin rash associated with glucagonoma.},
  author={Jeffrey A. Norton and C Ronald Kahn and Rick J Schiebinger and C M Gorschboth and Murray F. Brennan},
  journal={Annals of internal medicine},
  year={1979},
  volume={91 2},
  pages={213-5}
}
A 47-year-old white man had a malignant glucagonoma and severe necrolytic migratory erythema. His plasma glucagon levels were markedly elevated at 50 ng/mL and plasma amino acids diminished to 45% of normal. To test the hypothesis that the skin rash associated with a glucagonoma is secondary to an amino acid deficiency, we obtained 2 d of fasting baseline laboratory data from the patient while he consumed his usual diet. He was then given 3 L/d of supplemental intravenous amino acids for 3 d… CONTINUE READING