Amino acid control of the human glyceraldehyde 3-phosphate dehydrogenase gene transcription in hepatocyte.

@article{Claeyssens2003AminoAC,
  title={Amino acid control of the human glyceraldehyde 3-phosphate dehydrogenase gene transcription in hepatocyte.},
  author={Sophie Claeyssens and Christophe Gangneux and Carole G Brasse-Lagnel and Philippe Ruminy and Toshihiko Aki and Alain M Lavoinne and J P Salier},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2003},
  volume={285 5},
  pages={G840-9}
}
Glutamine (Gln) is the most potent of the amino acids (AAs) that regulate liver anabolism, and its effect is similar to that of insulin in peripheral tissues. However, the influence of AAs on regulation of metabolic enzyme-encoding genes is not known at the molecular level in liver. We now report that Gln and some essential AAs activate the human GAPDH gene that codes for GAPDH, a central enzyme of glycolysis and a target for insulin regulation. In HepG2 cells, Gln upregulated the GAPDH mRNA… CONTINUE READING

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