Amino acid changes within the E protein hinge region that affect dengue virus type 2 infectivity and fusion.

@article{Butrapet2011AminoAC,
  title={Amino acid changes within the E protein hinge region that affect dengue virus type 2 infectivity and fusion.},
  author={Siritorn Butrapet and Thomas Childers and Kelley J Moss and Steven M Erb and Betty E. Luy and Amanda E Calvert and Carol D. Blair and John T. Roehrig and Claire Y-H Huang},
  journal={Virology},
  year={2011},
  volume={413 1},
  pages={118-27}
}
Fifteen mutant dengue viruses were engineered and used to identify AAs in the molecular hinge of the envelope protein that are critical to viral infection. Substitutions at Q52, A54, or E133 reduced infectivity in mammalian cells and altered the pH threshold of fusion. Mutations at F193, G266, I270, or G281 affected viral replication in mammalian and mosquito cells, but only I270W had reduced fusion activity. T280Y affected the pH threshold for fusion and reduced replication in C6/36 cells… CONTINUE READING
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