Amino acid changes in Xrs2p, Dun1p, and Rfa2p that remove the preferred targets of the ATM family of protein kinases do not affect DNA repair or telomere length in Saccharomyces cerevisiae.

@article{Mallory2003AminoAC,
  title={Amino acid changes in Xrs2p, Dun1p, and Rfa2p that remove the preferred targets of the ATM family of protein kinases do not affect DNA repair or telomere length in Saccharomyces cerevisiae.},
  author={Julia C Mallory and Vladimir I. Bashkirov and Kelly M. Trujillo and Jachen A. Solinger and Margaret Dominska and Patrick Sung and Wolf-Dietrich Heyer and Thomas D Petes},
  journal={DNA repair},
  year={2003},
  volume={2 9},
  pages={1041-64}
}
In eukaryotes, mutations in a number of genes that affect DNA damage checkpoints or DNA replication also affect telomere length [Curr. Opin. Cell Biol. 13 (2001) 281]. Saccharomyces cerevisae strains with mutations in the TEL1 gene (encoding an ATM-like protein kinase) have very short telomeres, as do strains with mutations in XRS2, RAD50, or MRE11 (encoding members of a trimeric complex). Xrs2p and Mre11p are phosphorylated in a Tel1p-dependent manner in response to DNA damage [Genes Dev. 15… CONTINUE READING

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