Amino acid and structural variability of Yersinia pestis LcrV protein.

  title={Amino acid and structural variability of Yersinia pestis LcrV protein.},
  author={Andrey P Anisimov and Svetlana V. Dentovskaya and Evgeniy A Panfertsev and Tat'yana E Svetoch and Pavel Kh. Kopylov and Brent W. Segelke and Adam Zemla and Maxim V. Telepnev and Vladimir L. Motin},
  journal={Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases},
  volume={10 1},
The LcrV protein is a multifunctional virulence factor and protective antigen of the plague bacterium and is generally conserved between the epidemic strains of Yersinia pestis. We investigated the diversity in the LcrV sequences among non-epidemic Y. pestis strains which have a limited virulence in selected animal models and for humans. Sequencing of lcrV genes from 19 Y. pestis strains belonging to different phylogenetic groups (subspecies) showed that the LcrV proteins possess four major… CONTINUE READING
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