Amino Acids Regulate mTORC1 by an Obligate Two-step Mechanism.

@article{Dyachok2016AminoAR,
  title={Amino Acids Regulate mTORC1 by an Obligate Two-step Mechanism.},
  author={Julia Dyachok and Svetlana Earnest and Erica N Iturraran and Melanie H Cobb and Elliott M. Ross},
  journal={The Journal of biological chemistry},
  year={2016},
  volume={291 43},
  pages={22414-22426}
}
The mechanistic target of rapamycin complex 1 (mTORC1) coordinates cell growth with its nutritional, hormonal, energy, and stress status. Amino acids are critical regulators of mTORC1 that permit other inputs to mTORC1 activity. However, the roles of individual amino acids and their interactions in mTORC1 activation are not well understood. Here we… CONTINUE READING