Amino Acids, Independent of Insulin, Attenuate Skeletal Muscle Autophagy in Neonatal Pigs during Endotoxemia


Background:Sepsis induces loss of skeletal muscle mass by activating the ubiquitin proteasome (UPS) and autophagy systems. Although muscle protein synthesis in healthy neonatal piglets is responsive to amino acids (AA) stimulation, it is not known if AA can prevent the activation of muscle protein degradation induced by sepsis. We hypothesize that AA… (More)
DOI: 10.1038/pr.2016.83


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