Amino Acid Residues in the P2X7 Receptor that Mediate Differential Sensitivity to ATP and BzATP

@article{Young2007AminoAR,
  title={Amino Acid Residues in the P2X7 Receptor that Mediate Differential Sensitivity to ATP and BzATP},
  author={Mark T. Young and Pablo Pelegr{\'i}n and Annmarie Surprenant},
  journal={Molecular Pharmacology},
  year={2007},
  volume={71},
  pages={100 - 92}
}
Agonist properties of the P2X7 receptor (P2X7R) differ strikingly from other P2X receptors in two main ways: high concentrations of ATP (> 100 μM) are required to activate the receptor, and the ATP analog 2′,3′-O-(4-benzoyl-benzoyl)ATP (BzATP) is both more potent than ATP and evokes a higher maximum current. However, there are striking species differences in these properties. We sought to exploit the large differences in ATP and BzATP responses between rat and mouse P2X7R to delineate regions… 
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