Amino Acid Production from Methanol by Methylobacillus glycogenes Mutants: Isolation of L-Glutamic Acid Hyper-producing Mutants from M. glycogenes Strains, and Derivation of L-Threonine and L-Lysine-producing Mutants from Them.

@article{Motoyama1993AminoAP,
  title={Amino Acid Production from Methanol by Methylobacillus glycogenes Mutants: Isolation of L-Glutamic Acid Hyper-producing Mutants from M. glycogenes Strains, and Derivation of L-Threonine and L-Lysine-producing Mutants from Them.},
  author={Hideaki Motoyama and Hideharu Anazawa and Ryoichi Katsumata and Kazushi Araki and Sadao Teshiba},
  journal={Bioscience, biotechnology, and biochemistry},
  year={1993},
  volume={57 1},
  pages={
          82-7
        }
}
L-Glutamic acid (Glu) hyper-producing mutants were isolated from Methylobacillus glycogenes ATCC 21276 and ATCC 21371 during the screening of amino acid auxotrophs. iA111, derived from ATCC 21276, and 1009 (Phe(-)), derived from ATCC 21371, produced about 10 times as much Glu as the wild type strains. The highest producer, RV3, a phenylalanine auxotrophic revertant of 1009, produced 38.8 g/liters of Glu in 84h in a 5-liter jar fermentor. iA111 and 1009 were mutagenized, and L-threonine (Thr… CONTINUE READING
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