Amino Acid Deficiency and the Skin Rash Associated with Glucagonoma

  title={Amino Acid Deficiency and the Skin Rash Associated with Glucagonoma},
  author={Jeffrey A. Norton and C Ronald Kahn and Rick J Schiebinger and C M Gorschboth and Murray F. Brennan},
  journal={Annals of internal medicine},
  volume={91 2},
A 47-year-old white man had a malignant glucagonoma and severe necrolytic migratory erythema. His plasma glucagon levels were markedly elevated at 50 ng/mL and plasma amino acids diminished to 45% of normal. To test the hypothesis that the skin rash associated with a glucagonoma is secondary to an amino acid deficiency, we obtained 2 d of fasting baseline laboratory data from the patient while he consumed his usual diet. He was then given 3 L/d of supplemental intravenous amino acids for 3 d… CONTINUE READING


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