Amino Acid Catabolism in Multiple Sclerosis Affects Immune Homeostasis.

  title={Amino Acid Catabolism in Multiple Sclerosis Affects Immune Homeostasis.},
  author={Laura Negrotto and Jorge Correale},
  journal={Journal of immunology},
  volume={198 5},
Amino acid catabolism has been implicated in immunoregulatory mechanisms present in several diseases, including autoimmune disorders. Our aims were to assess expression and activity of enzymes involved in Trp and Arg catabolism, as well as to investigate amino acid catabolism effects on the immune system of multiple sclerosis (MS) patients. To this end, 40 MS patients, 30 healthy control subjects, and 30 patients with other inflammatory neurological diseases were studied. Expression and… CONTINUE READING
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