• Chemistry, Medicine
  • Published in
    Journal of pharmaceutical…
    2014
  • DOI:10.1002/jps.23949

Amine-containing molecules and the induction of an expanded lysosomal volume phenotype: a structure-activity relationship study.

@article{Logan2014AminecontainingMA,
  title={Amine-containing molecules and the induction of an expanded lysosomal volume phenotype: a structure-activity relationship study.},
  author={Randall Logan and Alex C Kong and Erick Axcell and Jeffrey P. Krise},
  journal={Journal of pharmaceutical sciences},
  year={2014},
  volume={103 5},
  pages={
          1572-80
        }
}
Many weakly basic amine-containing compounds have a strong propensity to become highly concentrated in lysosomes by virtue of an ion-trapping-type mechanism; the substrates for this are referred to as lysosomotropic. We have previously shown that many lysosomotropic drugs can produce a significant expansion in the apparent volume of lysosomes, which can ultimately result in an intracellular distribution-based drug-drug interaction. In this study, we have systematically evaluated the… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 46 REFERENCES

A high content screening assay for identifying lysosomotropic compounds.

  • Toxicology in vitro : an international journal published in association with BIBRA
  • 2011