Amine-Modified Poly(Vinyl Alcohol)s as Non-viral Vectors for siRNA Delivery: Effects of the Degree of Amine Substitution on Physicochemical Properties and Knockdown Efficiency

@article{Nguyen2010AmineModifiedPA,
  title={Amine-Modified Poly(Vinyl Alcohol)s as Non-viral Vectors for siRNA Delivery: Effects of the Degree of Amine Substitution on Physicochemical Properties and Knockdown Efficiency},
  author={Juliane Nguyen and Regina Reul and Susanne Roesler and Eyas Dayyoub and Thomas Schmehl and Tobias Gessler and Werner Seeger and Thomas H. Kissel},
  journal={Pharmaceutical Research},
  year={2010},
  volume={27},
  pages={2670-2682}
}
The objective of this study was to investigate how the degree of amine substitution of amine-modified poly(vinyl alcohol) (PVA) affects complexation of siRNA, protection of siRNA against degrading enzymes, intracellular uptake and gene silencing. A series of DEAPA-PVA polymers with increasing amine density was synthesized by modifying the hydroxyl groups in… CONTINUE READING