Amination of tyrosine in liver cytosol protein of male F344 rats treated with 2-nitropropane, 2-nitrobutane, 3-nitropentane, or acetoxime.

@article{Sodum1997AminationOT,
  title={Amination of tyrosine in liver cytosol protein of male F344 rats treated with 2-nitropropane, 2-nitrobutane, 3-nitropentane, or acetoxime.},
  author={Rama S. Sodum and Emerich S. Fiala},
  journal={Chemical research in toxicology},
  year={1997},
  volume={10 12},
  pages={
          1420-6
        }
}
  • R. Sodum, E. Fiala
  • Published 1 December 1997
  • Chemistry, Medicine
  • Chemical research in toxicology
Previously, the secondary nitroalkane 2-nitropropane, a strong hepatocarcinogen in rats, had been shown to induce the formation of 8-aminoguanine in both DNA and RNA of rat liver through a sulfotransferase-mediated pathway. This pathway was postulated to convert the carcinogen into an aminating species [Sodum, R. S., et al. (1994) Chem. Res. Toxicol. 7, 344-351]. To submit this postulate to further test, we examined liver proteins of rats treated with 2-nitropropane, other carcinogenic… 
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