Amiloride. Antiarrhythmic and electrophysiological activity in the dog.

Abstract

Amiloride, a widely used diuretic, has multiple pharmacological actions, including inhibition of the sodium-hydronium ion and the sodium-calcium exchanger in heart. In terms of cardiac electrophysiology, amiloride prolongs action potential duration without alteration in upstroke velocity of phase 0 in Purkinje fibers. The antiarrhythmic efficacy of… (More)

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Cite this paper

@article{Duff1988AmilorideAA, title={Amiloride. Antiarrhythmic and electrophysiological activity in the dog.}, author={Heather Duff and Will Lester and Magnus Rahmberg}, journal={Circulation}, year={1988}, volume={78 6}, pages={1469-77} }