Amiloride-sensitive channels are a major contributor to mechanotransduction in mammalian muscle spindles.

@article{Simon2010AmiloridesensitiveCA,
  title={Amiloride-sensitive channels are a major contributor to mechanotransduction in mammalian muscle spindles.},
  author={Anna Simon and Fiona C. Shenton and Irene Hunter and Robert W Banks and Guy Smith Bewick},
  journal={The Journal of physiology},
  year={2010},
  volume={588 Pt 1},
  pages={
          171-85
        }
}
We investigated whether channels of the epithelial sodium/amiloride-sensitive degenerin (ENaC/DEG) family are a major contributor to mechanosensory transduction in primary mechanosensory afferents, using adult rat muscle spindles as a model system. Stretch-evoked afferent discharge was reduced in a dose-dependent manner by amiloride and three analogues - benzamil, 5-(N-ethyl-N-isopropyl) amiloride (EIPA) and hexamethyleneamiloride (HMA), reaching > or = 85% inhibition at 1 mm. Moreover, firing… CONTINUE READING
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