Amiloride off-target effect inhibits podocyte urokinase receptor expression and reduces proteinuria.

@article{Zhang2012AmilorideOE,
  title={Amiloride off-target effect inhibits podocyte urokinase receptor expression and reduces proteinuria.},
  author={Bin Zhang and Shaoting Xie and Wei Shi and Yun Yang},
  journal={Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association},
  year={2012},
  volume={27 5},
  pages={1746-55}
}
The urokinase receptor (uPAR) and its soluble form play a key role in the pathogenesis of focal segmental glomerulosclerosis (FSGS). The modification of uPAR pathological actions on podocytes will become an important task for the development of improved nephroprotective therapeutics. Here we show that podocyte uPAR expression can be reduced using amiloride. Amiloride has a significant role in the reduction of podocyte cell motility in vitro and proteinuria in mice. Amiloride inhibited the… CONTINUE READING

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