Amiloride is a competitive inhibitor of coxsackievirus B 3 RNA polymerase 1 2 Running title : Amiloride is a competitive inhibitor of CVB 3 3 Dpol 3 4

@inproceedings{Gazina2011AmilorideIA,
  title={Amiloride is a competitive inhibitor of coxsackievirus B 3 RNA polymerase 1 2 Running title : Amiloride is a competitive inhibitor of CVB 3 3 Dpol 3 4},
  author={Elena V. Gazina and Eric D. Smidansky and Jessica K Holien and Donald F. Harrison and Jamie J Arnold and Michael W Parker and Craig E Cameron and Steven Petrou},
  year={2011}
}
24 25 Amiloride and its derivative 5-(N-ethyl-N-isopropyl)amiloride (EIPA) were previously shown to 26 inhibit coxsackievirus B3 (CVB3) RNA replication in cell culture, with two amino acid 27 substitutions in the viral RNA-dependent RNA polymerase 3D conferring partial resistance of 28 CVB3 to the compounds (D. N. Harrison, E. V. Gazina, D. F. Purcell, D. A. Anderson, and S. 29 Petrou, J. Virol. 82:1465-1473, 2008). Here, we demonstrate that amiloride and EIPA inhibit 30 enzymatic activity of… CONTINUE READING

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