Amiloride enhances the anticonvulsant action of various antiepileptic drugs in the mouse maximal electroshock seizure model

@article{Luszczki2008AmilorideET,
  title={Amiloride enhances the anticonvulsant action of various antiepileptic drugs in the mouse maximal electroshock seizure model},
  author={Jarogniew J Luszczki and Katarzyna M. Sawicka and Justyna Kozińska and Monika Dudra-Jastrzębska and Stanislaw J. Czuczwar},
  journal={Journal of Neural Transmission},
  year={2008},
  volume={116},
  pages={57-66}
}
Accumulating evidence indicates that amiloride (a potassium-sparing diuretic) exerts the anticonvulsant action in various in vivo and in vitro experiments. Therefore, the objective of this study was to assess the influence of amiloride on the protective action of numerous conventional and second-generation antiepileptic drugs [AEDs: carbamazepine (CBZ), lamotrigine (LTG), oxcarbazepine (OXC), phenobarbital (PB), topiramate (TPM), and valproate (VPA)] against maximal electroshock (MES)-induced… CONTINUE READING

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