Amiloride directly inhibits growth factor receptor tyrosine kinase activity.

@article{Davis1985AmilorideDI,
  title={Amiloride directly inhibits growth factor receptor tyrosine kinase activity.},
  author={R. Davis and M. Czech},
  journal={The Journal of biological chemistry},
  year={1985},
  volume={260 4},
  pages={
          2543-51
        }
}
  • R. Davis, M. Czech
  • Published 1985
  • Biology, Medicine
  • The Journal of biological chemistry
Addition of amiloride to A431 human epidermoid carcinoma cell membranes inhibited autophosphorylation of the epidermal growth factor (EGF) receptor. The tyrosine phosphorylation of histone H2B catalyzed by an affinity-purified preparation of EGF receptor was also inhibited by amiloride. The inhibition was noncompetitive with respect to histone but competitive with ATP, suggesting that amiloride may act as an ATP analogue which causes the formation of nonproductive enzyme-substrate complexes… Expand
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References

SHOWING 1-10 OF 31 REFERENCES
Insulin enhances protein phosphorylation in isolated hepatocytes by inhibiting an amiloride sensitive phosphatase.
Amiloride, protein synthesis, and activation of quiescent cells
...
1
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3
4
...