Amiloride-blockable acid-sensing ion channels are leading acid sensors expressed in human nociceptors.

  title={Amiloride-blockable acid-sensing ion channels are leading acid sensors expressed in human nociceptors.},
  author={Shinya Ugawa and Takashi Ueda and Yusuke Ishida and Makoto Nishigaki and Yasuhiro Shibata and Shoichi Shimada},
  journal={The Journal of clinical investigation},
  volume={110 8},
Many painful inflammatory and ischemic conditions such as rheumatoid arthritis, cardiac ischemia, and exhausted skeletal muscles are accompanied by local tissue acidosis. In such acidotic states, extracellular protons provoke the pain by opening cation channels in nociceptors. It is generally believed that a vanilloid receptor subtype-1 (VR1) and an acid-sensing ion channel (ASIC) mediate the greater part of acid-induced nociception in mammals. Here we provide evidence for the involvement of… CONTINUE READING
Highly Influential
This paper has highly influenced 12 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
Related Discussions
This paper has been referenced on Twitter 1 time. VIEW TWEETS


Publications citing this paper.
Showing 1-10 of 120 extracted citations

Nociceptors: a phylogenetic view

Journal of Comparative Physiology A • 2009
View 6 Excerpts
Highly Influenced

The use of rat spinal reflexes to quantify injection pain.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences • 2015
View 2 Excerpts
Highly Influenced

Venom toxins in the exploration of molecular, physiological and pathophysiological functions of acid-sensing ion channels.

Toxicon : official journal of the International Society on Toxinology • 2013
View 1 Excerpt
Highly Influenced

Modulation of acid-sensing ion channels: molecular mechanisms and therapeutic potential.

International journal of physiology, pathophysiology and pharmacology • 2011
View 4 Excerpts
Highly Influenced

Nerve growth factor-evoked nociceptor sensitization in pig skin in vivo.

Journal of neuroscience research • 2010
View 3 Excerpts
Highly Influenced


Publications referenced by this paper.
Showing 1-10 of 42 references

The tissue distribution and functional characterization of human VR1.

Biochemical and biophysical research communications • 2001
View 5 Excerpts
Highly Influenced

The vanilloid receptor: a molecular gateway to the pain pathway.

Annual review of neuroscience • 2001
View 5 Excerpts
Highly Influenced

Heteromultimers of DEG/ENaC subunits form H+-gated channels in mouse sensory neurons.

Proceedings of the National Academy of Sciences of the United States of America • 2002
View 6 Excerpts
Highly Influenced

Increased acid-sensing ion channel ASIC-3 in inflamed human intestine.

European journal of gastroenterology & hepatology • 2001
View 3 Excerpts

Similar Papers

Loading similar papers…