Amiloride analogues cause endothelium-dependent relaxation in the canine coronary artery in vitro: possible role of Na+/Ca2+ exchange.

@article{Cocks1988AmilorideAC,
  title={Amiloride analogues cause endothelium-dependent relaxation in the canine coronary artery in vitro: possible role of Na+/Ca2+ exchange.},
  author={T. M. Cocks and Peter J Little and James A. S. Angus and Edward J. Cragoe},
  journal={British journal of pharmacology},
  year={1988},
  volume={95 1},
  pages={67-76}
}
1. A number of amiloride analogues were used to test the proposal that Na+/Ca2+ exchange may play a role in the secretion of endothelium-derived relaxing factor (EDRF). The analogues used were those substituted on either the 5-amino group or the terminal guanidino nitrogen atom. The former block both Na+/Ca2+ and Na+/H+ exchange whilst the latter block the… CONTINUE READING