Amiloride-Sensitive Nasal Potential Difference Is Not Changed by Estradiol and Progesterone Replacement But Relates to BPD or Death in a Randomized Trial on Preterm Infants

@article{Thome2006AmilorideSensitiveNP,
  title={Amiloride-Sensitive Nasal Potential Difference Is Not Changed by Estradiol and Progesterone Replacement But Relates to BPD or Death in a Randomized Trial on Preterm Infants},
  author={Ulrich H. Thome and Aileen Bischoff and Ludwig Maier and Frank Pohlandt and Andreas Trotter},
  journal={Pediatric Research},
  year={2006},
  volume={60},
  pages={619-623}
}
Postnatal replacement of placental estradiol (E2) and progesterone (P) in preterm infants may improve lung function, possibly mediated through enhanced epithelial Na+ transport and alveolar fluid clearance. Preterm infants of <29 wk gestational age and <1000 g birth weight requiring mechanical ventilation within 12 h of birth were randomized to receive either 2.5 mg/kg E2 and 22.5 mg/kg P per day (E2/P), or vehicle placebo. Epithelial Na+ transport was assessed in 29 infants by measuring total… CONTINUE READING

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