Amikacin therapy for gram-negative septicemia.

  title={Amikacin therapy for gram-negative septicemia.},
  author={Richard D. Meyer and Richard P. Lewis and Sydney M. Finegold},
  journal={The American journal of medicine},
  volume={62 6},
Amikacin was administered to 18 patients with gram-negative septicemia. Ten of the patients had blood culture isolates highly resistant to gentamicin; six of these patients had persistent bacteremia while receiving gentamicin alone or in combination with other agents. Fourteen of the 18 patients were cured with amikacin therapy and adjunctive measures. Nine of the 10 patients with gentamicin-resistant pathogens were cured. The occurrence of nephrotoxicity in four patients with elevated amikacin… CONTINUE READING