Amikacin sulfate in mares: pharmacokinetics and body fluid and endometrial concentrations after repeated intramuscular administration.

@article{Brown1984AmikacinSI,
  title={Amikacin sulfate in mares: pharmacokinetics and body fluid and endometrial concentrations after repeated intramuscular administration.},
  author={Murray P. Brown and Rolf M. Embertson and Ronald R. Gronwall and Catherine B{\'e}al and I. G. Joe Mayhew and Sarah H Curry},
  journal={American journal of veterinary research},
  year={1984},
  volume={45 8},
  pages={1610-3}
}
Six mares were given 5 IM injections (at 12-hour intervals between doses) of amikacin sulfate at a dosage of 7 mg/kg of body weight. Serum amikacin concentrations were measured serially throughout the study; synovial, peritoneal, endometrial, and urine concentrations were determined after the last injection. Amikacin concentrations of the CSF were measured serially in 3 of the 6 mares; 1 of the 3 mares had septic meningitis. Mean serum amikacin concentrations peaked at 1 to 2 hours after IM… CONTINUE READING