Amifostine and glutathione prevent ifosfamide- and acrolein-induced hemorrhagic cystitis

  title={Amifostine and glutathione prevent ifosfamide- and acrolein-induced hemorrhagic cystitis},
  author={Clelma Pires Batista and Jos{\'e} Maur{\'i}cio Segundo Correia Mota and Marcellus Henrique Loiola Pontes de Souza and B. T. A. Leit{\~a}o and Gerly Anne Casto Brito and Fernando Q Cunha and Ronaldo de Albuquerque Ribeiro},
  journal={Cancer Chemotherapy and Pharmacology},
Introduction: Ifosfamide (IFS) is an antineoplastic alkylating agent whose major side effect is hemorrhagic cystitis (HC). This toxicity is attributed to the renal excretion of acrolein (ACR), a highly urotoxic IFS metabolite. Despite the clinical use of mesna to prevent HC, a significant percent (∼33%) of patients present with at last one feature of HC, mainly hematuria. Aim: To investigate the use of two antioxidants—amifostine and glutathione—for the prevention of experimental IFS- and ACR… CONTINUE READING


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