Amifostine and glutathione prevent ifosfamide- and acrolein-induced hemorrhagic cystitis

@article{Batista2006AmifostineAG,
  title={Amifostine and glutathione prevent ifosfamide- and acrolein-induced hemorrhagic cystitis},
  author={Clelma Pires Batista and Jos{\'e} Maur{\'i}cio Segundo Correia Mota and Marcellus Henrique Loiola Pontes de Souza and B. T. A. Leit{\~a}o and Gerly Anne Casto Brito and Fernando Q Cunha and Ronaldo de Albuquerque Ribeiro},
  journal={Cancer Chemotherapy and Pharmacology},
  year={2006},
  volume={59},
  pages={71-77}
}
Introduction: Ifosfamide (IFS) is an antineoplastic alkylating agent whose major side effect is hemorrhagic cystitis (HC). This toxicity is attributed to the renal excretion of acrolein (ACR), a highly urotoxic IFS metabolite. Despite the clinical use of mesna to prevent HC, a significant percent (∼33%) of patients present with at last one feature of HC, mainly hematuria. Aim: To investigate the use of two antioxidants—amifostine and glutathione—for the prevention of experimental IFS- and ACR… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 21 extracted citations

Protective effect of ketamine against hemorrhagic cystitis in rats receiving ifosfamide

Indian journal of pharmacology • 2014
View 7 Excerpts
Highly Influenced

Benefit of Satureja khuzestanica in subchronically rat model of cyclophosphamide-induced hemorrhagic cystitis.

Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie • 2010
View 1 Excerpt

References

Publications referenced by this paper.
Showing 1-10 of 21 references

Chemoprotectants—a review of their clinical phamacology and therapeutic efficacy

M Links, C Lewis
Drugs • 1999
View 5 Excerpts
Highly Influenced

Use of dexamethasone with mesna for the prevention of ifosfamide-induced hemorrhagic cystitis.

International journal of urology : official journal of the Japanese Urological Association • 2003
View 1 Excerpt

Similar Papers

Loading similar papers…