Amides of non-steroidal anti-inflammatory drugs with thiomorpholine can yield hypolipidemic agents with improved anti-inflammatory activity.

@article{TheodosisNobelos2016AmidesON,
  title={Amides of non-steroidal anti-inflammatory drugs with thiomorpholine can yield hypolipidemic agents with improved anti-inflammatory activity.},
  author={Panagiotis Theodosis-Nobelos and Malamati Kourti and Antonios M Gavalas and Eleni A. Rekka},
  journal={Bioorganic & medicinal chemistry letters},
  year={2016},
  volume={26 3},
  pages={910-913}
}
Novel amides of non steroidal anti-inflammatory drugs (NSAIDs), α-lipoic acid and indole-3-acetic acid with thiomorpholine were synthesised by a simple method and at high yields (60-92%). All the NSAID derivatives highly decreased lipidemic indices in the plasma of Triton treated hyperlipidemic rats. The most potent compound was the indomethacin derivative… CONTINUE READING