Amide solvent protection analysis demonstrates that amyloid-β ( 1 – 40 ) and amyloid-β ( 1 – 42 ) form different fibrillar structures under identical conditions

AD (Alzheimer’s disease) is a neurodegenerative disorder characterized by self-assembly and amyloid formation of the 39–43 residue long Aβ (amyloid-β)-peptide. The most abundant species, Aβ(1–40) and Aβ(1–42), are both present within senile plaques, but Aβ(1–42) peptides are considerably more prone to selfaggregation and are also essential for the… CONTINUE READING