Amide Local Anesthetics Potently Inhibit the Human Tandem Pore Domain Background K+ Channel TASK-2 (KCNK5)

@article{Kindler2003AmideLA,
  title={Amide Local Anesthetics Potently Inhibit the Human Tandem Pore Domain Background K+ Channel TASK-2 (KCNK5)},
  author={C. Kindler and Matthias Paul and H. Zou and Canhui Liu and B. Winegar and A. Gray and C. Yost},
  journal={Journal of Pharmacology and Experimental Therapeutics},
  year={2003},
  volume={306},
  pages={84 - 92}
}
  • C. Kindler, Matthias Paul, +4 authors C. Yost
  • Published 2003
  • Chemistry, Medicine
  • Journal of Pharmacology and Experimental Therapeutics
  • Blockade of voltage-gated sodium (Na+) channels by local anesthetics represents the main mechanism for inhibition of impulse propagation. Local anesthetic-induced potassium (K+) channel inhibition is also known to influence transmission of sensory impulses and to potentiate inhibition. K+ channels involved in this mechanism may belong to the emerging family of background tandem pore domain K+ channels (2P K+ channels). To determine more precisely the effects of local anesthetics on members of… CONTINUE READING
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    References

    SHOWING 1-10 OF 54 REFERENCES
    Local anesthetic inhibition of baseline potassium channels with two pore domains in tandem.
    • 116
    Molecular determinants of state-dependent block of Na+ channels by local anesthetics.
    • 762
    Mechanism underlying bupivacaine inhibition of G protein-gated inwardly rectifying K+ channels
    • 75
    • PDF
    Volatile Anesthetics Activate the Human Tandem Pore Domain Baseline K+ Channel KCNK5
    • 73
    • PDF
    Stereoselective block of a human cardiac potassium channel (Kv1.5) by bupivacaine enantiomers.
    • 166
    Block of the background K(+) channel TASK-1 contributes to arrhythmogenic effects of platelet-activating factor.
    • 62
    • PDF
    A functional role for the two-pore domain potassium channel TASK-1 in cerebellar granule neurons.
    • 249
    • PDF
    Modulation of TASK-1 (Kcnk3) and TASK-3 (Kcnk9) Potassium Channels
    • 170
    • Highly Influential
    • PDF
    CNS Distribution of Members of the Two-Pore-Domain (KCNK) Potassium Channel Family
    • 496
    • Highly Influential
    • PDF