Amide Local Anesthetics Potently Inhibit the Human Tandem Pore Domain Background K+ Channel TASK-2 (KCNK5)
@article{Kindler2003AmideLA, title={Amide Local Anesthetics Potently Inhibit the Human Tandem Pore Domain Background K+ Channel TASK-2 (KCNK5)}, author={C. Kindler and Matthias Paul and H. Zou and Canhui Liu and B. Winegar and A. Gray and C. Yost}, journal={Journal of Pharmacology and Experimental Therapeutics}, year={2003}, volume={306}, pages={84 - 92} }
Blockade of voltage-gated sodium (Na+) channels by local anesthetics represents the main mechanism for inhibition of impulse propagation. Local anesthetic-induced potassium (K+) channel inhibition is also known to influence transmission of sensory impulses and to potentiate inhibition. K+ channels involved in this mechanism may belong to the emerging family of background tandem pore domain K+ channels (2P K+ channels). To determine more precisely the effects of local anesthetics on members of… CONTINUE READING
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References
SHOWING 1-10 OF 54 REFERENCES
Local anesthetic inhibition of baseline potassium channels with two pore domains in tandem.
- Medicine
- Anesthesiology
- 1999
- 116
Molecular determinants of state-dependent block of Na+ channels by local anesthetics.
- Biology, Medicine
- Science
- 1994
- 762
Mechanism underlying bupivacaine inhibition of G protein-gated inwardly rectifying K+ channels
- Chemistry, Medicine
- Proceedings of the National Academy of Sciences of the United States of America
- 2001
- 75
- PDF
Volatile Anesthetics Activate the Human Tandem Pore Domain Baseline K+ Channel KCNK5
- Medicine
- Anesthesiology
- 2000
- 73
- PDF
Stereoselective block of a human cardiac potassium channel (Kv1.5) by bupivacaine enantiomers.
- Chemistry, Medicine
- Biophysical journal
- 1995
- 166
Block of the background K(+) channel TASK-1 contributes to arrhythmogenic effects of platelet-activating factor.
- Chemistry, Medicine
- American journal of physiology. Heart and circulatory physiology
- 2002
- 62
- PDF
A functional role for the two-pore domain potassium channel TASK-1 in cerebellar granule neurons.
- Biology, Medicine
- Proceedings of the National Academy of Sciences of the United States of America
- 2000
- 249
- PDF
Fundamental Properties of Local Anesthetics: Half-Maximal Blocking Concentrations for Tonic Block of Na+ and K+ Channels in Peripheral Nerve
- Medicine
- Anesthesia and analgesia
- 1998
- 84
Modulation of TASK-1 (Kcnk3) and TASK-3 (Kcnk9) Potassium Channels
- Chemistry, Medicine
- The Journal of Biological Chemistry
- 2002
- 170
- Highly Influential
- PDF
CNS Distribution of Members of the Two-Pore-Domain (KCNK) Potassium Channel Family
- Biology, Medicine
- The Journal of Neuroscience
- 2001
- 496
- Highly Influential
- PDF