Amide Local Anesthetics Potently Inhibit the Human Tandem Pore Domain Background K+ Channel TASK-2 (KCNK5)

  title={Amide Local Anesthetics Potently Inhibit the Human Tandem Pore Domain Background K+ Channel TASK-2 (KCNK5)},
  author={C. Kindler and Matthias Paul and H. Zou and Canhui Liu and B. Winegar and A. Gray and C. Yost},
  journal={Journal of Pharmacology and Experimental Therapeutics},
  pages={84 - 92}
  • C. Kindler, Matthias Paul, +4 authors C. Yost
  • Published 2003
  • Chemistry, Medicine
  • Journal of Pharmacology and Experimental Therapeutics
  • Blockade of voltage-gated sodium (Na+) channels by local anesthetics represents the main mechanism for inhibition of impulse propagation. Local anesthetic-induced potassium (K+) channel inhibition is also known to influence transmission of sensory impulses and to potentiate inhibition. K+ channels involved in this mechanism may belong to the emerging family of background tandem pore domain K+ channels (2P K+ channels). To determine more precisely the effects of local anesthetics on members of… CONTINUE READING
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