Amfenac increases the radiosensitivity of uveal melanoma cell lines

  title={Amfenac increases the radiosensitivity of uveal melanoma cell lines},
  author={Bruno Franco Fernandes and J Marshall and Sebastian Di Cesare and Patrick Logan and Shawn Maloney and Miguel Noel Burnier},
PurposeTo evaluate the proliferation rates of five human uveal melanoma (UM) cell lines after treatment with amfenac, a cyclooxygenase (COX)-2 inhibitor, and subsequent radiation exposure.MethodsFive human UM cell lines (92.1, SP6.5, MKT-BR, OCM-1, and UW-1) and one human fibroblast cell line (BJ) were incubated with amfenac. Treated and non-treated cell lines were then exposed to various doses of γradiation: 0, 2, 4, 6, and 8 Gy. Sulphorhodamine-B assay was used to assess proliferation rates… CONTINUE READING
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