Ames Waltzer deaf mice have reduced electroretinogram amplitudes and complex alternative splicing of Pcdh15 transcripts.

@article{HaywoodWatson2006AmesWD,
  title={Ames Waltzer deaf mice have reduced electroretinogram amplitudes and complex alternative splicing of Pcdh15 transcripts.},
  author={Ricky J. L. Haywood-Watson and Z M Ahmed and Sten Kjellstrom and Ronald A. Bush and Yuichiro Takada and Lori L. Hampton and James F. Battey and Paul A. Sieving and Thomas B Friedman},
  journal={Investigative ophthalmology & visual science},
  year={2006},
  volume={47 7},
  pages={3074-84}
}
PURPOSE Mutations of PCDH15, the gene encoding protocadherin 15, cause either nonsyndromic deafness DFNB23 or Usher syndrome type 1F (USH1F) in humans and deafness with balance problems in Ames waltzer (av) mice. Persons with USH1 usually begin to exhibit signs of retinitis pigmentosa (RP) in early adolescence, but av mice are reported to have functional… CONTINUE READING