American tegumentary leishmaniasis: Is antimonial treatment outcome related to parasite drug susceptibility?

@article{Yardley2006AmericanTL,
  title={American tegumentary leishmaniasis: Is antimonial treatment outcome related to parasite drug susceptibility?},
  author={Vanessa Yardley and Nimer Ortuno and Alejandro Llanos-Cuentas and François Chappuis and Simonne De Doncker and Luis Ramirez and Simon Croft and Jorge Luiz Sanches Arevalo and Vanessa Adaui and H. Duran Bermudez and Saskia Decuypere and J. Cl. Dujardin},
  journal={The Journal of infectious diseases},
  year={2006},
  volume={194 8},
  pages={
          1168-75
        }
}
BACKGROUND Antimonials are the first drug of choice for the treatment of American tegumentary leishmaniasis (ATL); however, their efficacy is not predictable, and this may be linked to parasite drug resistance. We aimed to characterize the in vitro antimony susceptibility of clinical isolates of Peruvian patients with ATL who were treated with sodium stibogluconate and to correlate this in vitro phenotype with different treatment outcomes. METHODS Thirty-seven clinical isolates were obtained… CONTINUE READING

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