Amentoflavone from Biophytum sensitivum and its effect on COX-1/COX-2 catalysed prostaglandin biosynthesis.

Abstract

Amentoflavone (I3', II8-biapigenin) was isolated from the roots of Biophytum sensitivum DC. (Oxalidaceae) and proved to be a selective inhibitor of cyclooxygenase (COX)-1 catalysed prostaglandin biosynthesis when tested in vitro with an IC (50) value of 12.4 microM (standard: indomethacin, IC (50) = 1.1 microM). Doses of up to 37 microM showed only a slight… (More)

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@article{Bucar1998AmentoflavoneFB, title={Amentoflavone from Biophytum sensitivum and its effect on COX-1/COX-2 catalysed prostaglandin biosynthesis.}, author={Franjo Bucar and Sanjay Madhukar Jachak and Y Noreem and Thomas Kartnig and P. Perera and Lars Bohlin and Manfred Schubert-Zsilavecz}, journal={Planta medica}, year={1998}, volume={64 4}, pages={373-4} }