Ameliorative potential of pioglitazone and ceftriaxone alone and in combination in rat model of neuropathic pain: Targeting PPARγ and GLT-1 pathways.

@article{Pottabathini2016AmeliorativePO,
  title={Ameliorative potential of pioglitazone and ceftriaxone alone and in combination in rat model of neuropathic pain: Targeting PPARγ and GLT-1 pathways.},
  author={Raghavender Pottabathini and Anil Kumar and Archana Bhatnagar and Sukant Garg and E Ekavali},
  journal={Pharmacological reports : PR},
  year={2016},
  volume={68 1},
  pages={85-94}
}
BACKGROUND The relation between glutamate homeostasis and PPAR gamma has got tremendous importance in nerve trauma and pain. Present study has been designed to elucidate the interaction between the GLT-1 activator (ceftriaxone) and PPAR gamma agonist (pioglitazone) in the spinal nerve ligation induced neuropathic pain. METHODS Male SD rats were subjected to spinal nerve ligation to induce neuropathic pain. Pioglitazone, ceftriaxone and their combination treatments were given for 28 days… CONTINUE READING
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