Ameliorative effect of hepatocyte growth factor on glycerol-induced acute renal failure with acute tubular necrosis.


BACKGROUND/AIMS Hepatocyte growth factor (HGF), a multi-potent growth factor, is known to promote regeneration of damaged renal epithelial cells. Glycerol injection into rats induces severe acute renal failure (ARF) with ischemia and tubular necrosis, a model which shares many features with human ARF or rhabdomyolysis. We investigated the efficacy of HGF in… (More)


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