Ameliorative effect of MK-801 on retinal ischemia.

  title={Ameliorative effect of MK-801 on retinal ischemia.},
  author={Tim Tak Lam and Edward Siew and Ren-yuan Chu and Mark O. M. Tso},
  journal={Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics},
  volume={13 2},
The efficacy of MK-801, an N-methyl-D-aspartate receptor antagonist, was evaluated in a rat model of retinal ischemia induced by elevated intraocular pressure. Intraperitoneal injection of MK-801 at 0, 1, 3 and 10 mg/kg was given immediately after reperfusion. At 7 days after reperfusion, the inner retinal thickness, as measured from histologic sections of the retinas, of the 10 mg/kg treated group showed significant beneficial effect, while the other doses had no significant effect. Retinal… CONTINUE READING


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