Ameliorative effect of Aegle marmelos leaf extract on early stage alloxan-induced diabetic cardiomyopathy in rats.

@article{Bhatti2011AmeliorativeEO,
  title={Ameliorative effect of Aegle marmelos leaf extract on early stage alloxan-induced diabetic cardiomyopathy in rats.},
  author={Rajbir Singh Bhatti and Shikha Sharma and Jatinder Singh and Mohan Paul Singh Ishar},
  journal={Pharmaceutical biology},
  year={2011},
  volume={49 11},
  pages={1137-43}
}
OBJECTIVE The pathogenesis of diabetic cardiomyopathy (DCM) is complex, and the therapeutic options available to treat DCM are limited. The present study was designed to investigate the effect of Aegle marmelos (L.) Correa (Rutaceae) leaf extract on early stage DCM in alloxan-induced diabetic rats. METHODS Diabetes was induced in Wistar rats (150-200 g) by injecting alloxan (150 mg kg(-1); i.p.). Ethanol extract of A. marmelos leaves was administered at varying doses (100, 200, and 400 mg kg… CONTINUE READING
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