• Corpus ID: 55282279

Ameliorative Effect of Rutin on Gentamicin-Induced Nephrotoxicity in Murine Model

@inproceedings{Ramhariya2015AmeliorativeEO,
  title={Ameliorative Effect of Rutin on Gentamicin-Induced Nephrotoxicity in Murine Model},
  author={Ruchi Ramhariya and Aditya Ganeshpurkar and Chitrangada Ayachi and P Kanojia and Nazneen Dubey and Shri Paras Ram and Ganeshpurkar Aditya},
  year={2015}
}
Gentamicin is one of the widely used antibiotics. However, it suffers from drawback of nephrotoxicity, which is predisposed due to oxidative stress. Rutin is one of the major classes of flavonoids and phyto-antioxidant. It has demonstrated cardioprotective, hepatoprotective and neuroprotective effects. However, no studies pertaining to its nephroprotective activity have still performed. Present work was aimed to determine nephroprotective activity of Rutin. Dose of 100 mg/ kg and 200 mg/ kg was… 

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References

SHOWING 1-10 OF 33 REFERENCES

The Synergistic Effects of Rutin and Urate Oxidase on Nephrotoxicity in Rats

All the previous parameters were corrected to some extent after the nephrotoxic rats treated with rutin, urate oxidase and their combination.

Protective effects of capsaicin against cisplatin-induced nephrotoxicity in rats.

It is suggested that capsaicin has protective effects against cisplatin-induced nephrotoxicity and lipid peroxidation in rats.

Effects of rutin on acrylamide-induced neurotoxicity

It seems that rutin could be effective in reducing neurotoxicity and the neuroprotective effect of it might be mediated via antioxidant activity.

A role for superoxide in gentamicin-mediated nephropathy in rats.

An experimetal evaluation of nephroprotective potential of Butea monosperma extract in albino rats

It is revealed that ethanolic extract of Butea monosperma is a good source of phytochemicals and the phytoconstituents flavonoids, phenolics, and alkaloids present in the extracts may be responsible for antioxidant activity.

Effects of Fennel Essential Oil on Cisplatin-induced Nephrotoxicity in Ovariectomized Rats

FEO, as a source of phytoestrogen, did not induce kidney damage and FEO similar to estrogen was not a nephroprotectant agent against CDDP-induced nephrotoxicity.

Rutin, a bioflavonoid antioxidant protects rat pheochromocytoma (PC-12) cells against 6-hydroxydopamine (6-OHDA)-induced neurotoxicity.

It was concluded that the bioflavonoid rutin inhibited 6-OHDA-induced neurotoxicity in PC-12 cells by improving antioxidant enzyme levels and inhibiting lipid peroxidation.

A model for prediction of cisplatin induced nephrotoxicity by kidney weight in experimental rats

Normalized kidney weight and pathology damage score is a good predictor of renal function in cisplatin induced nephrotoxicity in experimental rats.