• Corpus ID: 55282279

Ameliorative Effect of Rutin on Gentamicin-Induced Nephrotoxicity in Murine Model

@inproceedings{Ramhariya2015AmeliorativeEO,
  title={Ameliorative Effect of Rutin on Gentamicin-Induced Nephrotoxicity in Murine Model},
  author={Ruchi Ramhariya and Aditya Ganeshpurkar and Chitrangada Ayachi and P Kanojia and Nazneen Dubey and Shri Paras Ram and Ganeshpurkar Aditya},
  year={2015}
}

• Ruchi Ramhariya, A. Ganeshpurkar, +4 authors Ganeshpurkar Aditya
• Published 2015
• Biology, Medicine

Gentamicin is one of the widely used antibiotics. However, it suffers from drawback of nephrotoxicity, which is predisposed due to oxidative stress. Rutin is one of the major classes of flavonoids and phyto-antioxidant. It has demonstrated cardioprotective, hepatoprotective and neuroprotective effects. However, no studies pertaining to its nephroprotective activity have still performed. Present work was aimed to determine nephroprotective activity of Rutin. Dose of 100 mg/ kg and 200 mg/ kg was taken in present study. Gentamicin (80 mg/ kg) was used to induce nephrotoxicity. At the end of the study body weight, kidney weight, serum creatinine, serum urea, blood urea nitrogen and urine creatinine were determined along with histopathological studies. Administration of Rutin restored the levels of biomarkers. Histopathological studies also demonstrated protective effect on kidney. Thus it could be concluded that rutin demonstrates nephroprotective potential.