Amelioration of untreated restless legs syndrome by tadalafil in a patient with erectile dysfunction.


T o the Editor: Tadalafil is a long-acting phosphodiesterase type 5 (PDE5) inhibitor effective for erectile dysfunction (ED). The efficacy of PDE5 inhibitors is ascribed to their ability to amplify the activity of the nitric oxide–3,5-cyclic guanosine monophosphate (cGMP) signaling pathway. Altered circadian dopaminergic modulation of neuronal excitability… (More)
DOI: 10.1097/WNF.0000000000000070


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