Amelioration of the haloperidol-induced memory impairment and brain oxidative stress by cinnarizine

@inproceedings{AbdelSalam2012AmeliorationOT,
  title={Amelioration of the haloperidol-induced memory impairment and brain oxidative stress by cinnarizine },
  author={Omar M. E. Abdel-Salam and Marwa El-Sayed El-Shamarka and Neveen A Salem and Aliaa E.M.K. El-Mosallamy and Amany Ameen Sleem},
  booktitle={EXCLI journal},
  year={2012}
}
Haloperidol is a classic antipsychotic drug known for its propensity to cause extrapyramidal symptoms and impaired memory, owing to blockade of striatal dopamine D2 receptors. Cinnarizine is a calcium channel blocker with D2 receptor blocking properties which is widely used in treatment of vertiginous disorders. The present study aimed to see whether cinnarizine would worsen the effect of haloperidol on memory function and on oxidative stress in mice brain. Cinnarizine (5, 10 or 20 mg/kg… CONTINUE READING

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