Amelioration of the cost of conjugative plasmid carriage in Eschericha coli K12.

@article{Dahlberg2003AmeliorationOT,
  title={Amelioration of the cost of conjugative plasmid carriage in Eschericha coli K12.},
  author={Cecilia Dahlberg and Lin Rui Chao},
  journal={Genetics},
  year={2003},
  volume={165 4},
  pages={1641-9}
}
Although plasmids can provide beneficial functions to their host bacteria, they might confer a physiological or energetic cost. This study examines how natural selection may reduce the cost of carrying conjugative plasmids with drug-resistance markers in the absence of antibiotic selection. We studied two plasmids, R1 and RP4, both of which carry multiple drug resistance genes and were shown to impose an initial fitness cost on Escherichia coli. To determine if and how the cost could be reduced… CONTINUE READING