• DOI:10.1002/JAT.955
• Corpus ID: 29619354

Amelioration of sulfur mustard skin injury following a topical treatment with a mixture of a steroid and a NSAID

@article{Dachir2004AmeliorationOS,
  title={Amelioration of sulfur mustard skin injury following a topical treatment with a mixture of a steroid and a NSAID},
  author={Shlomit Dachir and Eliezer Fishbeine and Yakov Meshulam and Rita Sahar and Shira Chapman and Adina Amir and Tamar Kadar},
  journal={Journal of Applied Toxicology},
  year={2004},
  volume={24}
}

• S. Dachir, E. Fishbeine, +4 authors T. Kadar
• Published 1 March 2004
• Medicine, Biology
• Journal of Applied Toxicology

The ability to ameliorate sulfur mustard (HD)‐induced oedema by treatment with anti‐inflammatory drugs was reported previously after screening four steroids and four non‐steroidal anti‐inflammatory drugs (NSAIDs) using the mouse ear vesicant model. Following the screening study, one steroid and one NSAID (Adexone and Voltaren) were selected as the most effective, and a mixture of the two was chosen for the present more extensive research. The effect of the combined treatment on clinical, biochemical and histopathological parameters following HD insult was studied. Mice ears were exposed to 0.2 µl of HD for 10 min to produce a moderate skin injury. Oedema development peaked ca. 48 h following exposure, as determined by weighing ear biopsies. Histological observations at that time exhibited damage to the epidermis and dermis. An increase in prostaglandin E (PGE) was measured in skin homogenates, starting 8 h following exposure and lasting at least up to 48 h post‐exposure.