Amelioration of sulfur mustard skin injury following a topical treatment with a mixture of a steroid and a NSAID

  title={Amelioration of sulfur mustard skin injury following a topical treatment with a mixture of a steroid and a NSAID},
  author={Shlomit Dachir and Eliezer Fishbeine and Yakov Meshulam and Rita Sahar and Shira Chapman and Adina Amir and Tamar Kadar},
  journal={Journal of Applied Toxicology},
The ability to ameliorate sulfur mustard (HD)‐induced oedema by treatment with anti‐inflammatory drugs was reported previously after screening four steroids and four non‐steroidal anti‐inflammatory drugs (NSAIDs) using the mouse ear vesicant model. Following the screening study, one steroid and one NSAID (Adexone and Voltaren) were selected as the most effective, and a mixture of the two was chosen for the present more extensive research. The effect of the combined treatment on clinical… 

Selection of non-steroidal anti-inflammatory drug and treatment regimen for sulfur mustard-induced cutaneous lesions

A combination of diclofenac and clobetasol application, when administered for at least five days, shows promise in ameliorating HD-induced lesions.

Beneficial effects of activated macrophages on sulfur mustard-induced cutaneous burns, an in vivo experience

The results indicate that the role of macrophages in wound healing is complex; their efficacy may depend on the timing of administration.

Characterization of acute and long‐term sulfur mustard‐induced skin injuries in hairless guinea‐pigs using non‐invasive methods

  • S. DachirMaayan Cohen T. Kadar
  • Medicine, Biology
    Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging
  • 2010
The aim of the present study was to establish a small animal model for a long‐term HD‐induced skin injury using the hairless guinea‐pig (HGP) and to further test the efficacy of anti‐inflammatories in ameliorating the pathology.

Mechanisms mediating the vesicant actions of sulfur mustard after cutaneous exposure.

Successful therapy for SM poisoning will depend on following new mechanistic leads to develop drugs that target one or more of its sites of action, as well as potential mechanisms mediating its actions.

Use of the mouse ear vesicant model to evaluate the effectiveness of ebselen as a countermeasure to the nitrogen mustard mechlorethamine

The hypothesis that EB‐1 will reduce dermal toxicity of HN2 in vivo is put forward and found to have merit and the effectiveness ofEB‐1 as a vesicant countermeasure in a relevant in vivo model is demonstrated.

Corneal toxicity induced by vesicating agents and effective treatment options

Primary humanCorneal epithelial cells and rabbit corneal organ culture models are established with the SM analog nitrogen mustard and LEW, which have helped to test the efficacy of potential therapeutic agents and assist in the development of potential broad‐spectrum therapies against vesicant‐induced ocular injuries.

Treatment of sulphur mustard skin injury.

Antioxidant/stress response in mouse epidermis following exposure to nitrogen mustard.

Sulfur Mustard Research—Strategies for the Development of Improved Medical Therapy

Polymerase inhibitors, anti-inflammatory drugs, antioxidants, matrix metalloproteinase inhibitor, and probably regulators of DNA damage repair are identified as promising approaches to improve treatment.