Amelioration of sepsis by TIE2 activation–induced vascular protection

  title={Amelioration of sepsis by TIE2 activation–induced vascular protection},
  author={Sangyeul Han and Seung-Jun Lee and Kyung Eun Kim and Hyo Seon Lee and Nuri Oh and Inwon Park and Eun Young Ko and Seung Ja Oh and Y Lee and David Hong Kyun Kim and Seungjoo Lee and Dae Hyun Lee and K Lee and Su Young Chae and Jung-Hoon Lee and Su-Jin Kim and Hyung-Chan Kim and Seokkyun Kim and Sung Hyun Kim and Chungho Kim and Yoshikazu Nakaoka and Yulong He and Hellmut G Augustin and Junhao Hu and Paul H. Song and Yong-In Kim and Pilhan Kim and Injune Kim and Gou Young Koh},
  journal={Science Translational Medicine},
Protection of endothelial integrity has been recognized as a frontline approach to alleviating sepsis progression, yet no effective agent for preserving endothelial integrity is available. Using an unusual anti–angiopoietin 2 (ANG2) antibody, ABTAA (ANG2-binding and TIE2-activating antibody), we show that activation of the endothelial receptor TIE2 protects the vasculature from septic damage and provides survival benefit in three sepsis mouse models. Upon binding to ANG2, ABTAA triggers… CONTINUE READING
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