Amelioration of renal ischemia-reperfusion injury with a novel protective cocktail.

@article{Dorai2011AmeliorationOR,
  title={Amelioration of renal ischemia-reperfusion injury with a novel protective cocktail.},
  author={Thambi Dorai and Andrew I. Fishman and Cheng Ding and Ines Batini{\'c}-Haberle and David S. Goldfarb and Michael A Grasso},
  journal={The Journal of urology},
  year={2011},
  volume={186 6},
  pages={2448-54}
}
PURPOSE Extended warm ischemia during partial nephrectomy can lead to considerable renal injury. Using a rat model of renal ischemia we examined the ability of a unique renoprotective cocktail to ameliorate warm ischemia-reperfusion injury. MATERIALS AND METHODS A warm renal ischemia model was developed using 60 Sprague-Dawley® rats. The left renal artery was clamped for 40 minutes, followed by 48 hours of reperfusion. A renoprotective cocktail of a mixture of specific growth factors… CONTINUE READING
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