Amelioration of renal ischaemia-reperfusion injury by synthetic oligopeptides related to human chorionic gonadotropin.

@article{Khan2009AmeliorationOR,
  title={Amelioration of renal ischaemia-reperfusion injury by synthetic oligopeptides related to human chorionic gonadotropin.},
  author={Nisar Ahmed Khan and Denis Susa and Jan Willem K. van den Berg and Martin Huisman and Miriam H Ameling and Sandra van den Engel and Henk P. Roest and Jan Nicolaas Maria Ijzermans and Willem A. Dik and Robbert Benner and Ron W. F. de Bruin},
  journal={Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association},
  year={2009},
  volume={24 9},
  pages={2701-8}
}
BACKGROUND We have previously reported that small synthetic oligopeptides related to human beta-chorionic gonadotropin (beta-hCG) can reduce inflammation. Here we investigated whether such oligopeptides can reduce renal ischaemia-reperfusion injury in the mouse. METHODS Ten different oligopeptides were administered 1 min before induction of renal ischaemia and 1 min before reperfusion. RESULTS Survival at 72 h post-reperfusion was significantly higher in mice treated with oligopeptides MTRV… CONTINUE READING